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| The dorsolateral pre‑frontal cortex bi‑polar error‑related potential in a locked‑in patient implanted with a daily use brain–computer interface |
| ZacharyFreudenburg,KhaterahKohneshin,ErikAarnoutse,MariskaVansteensel,MarianaBranco,SachaLeinders,MaxvandenBoom,ElmarG.M.Pels,NickRamsey |
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| (Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands) |
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| 摘要: |
| While brain computer interfaces (BCIs) offer the potential of allowing those suffering from loss of muscle control to once
again fully engage with their environment by bypassing the affected motor system and decoding user intentions directly from
brain activity, they are prone to errors. One possible avenue for BCI performance improvement is to detect when the BCI user
perceives the BCI to have made an unintended action and thus take corrective actions. Error-related potentials (ErrPs) are
neural correlates of error awareness and as such can provide an indication of when a BCI system is not performing according
to the user’s intentions. Here, we investigate the brain signals of an implanted BCI user suffering from locked-in syndrome
(LIS) due to late-stage ALS that prevents her from being able to speak or move but not from using her BCI at home on a
daily basis to communicate, for the presence of error-related signals. We first establish the presence of an ErrP originating
from the dorsolateral pre-frontal cortex (dLPFC) in response to errors made during a discrete feedback task that mimics the
click-based spelling software she uses to communicate. Then, we show that this ErrP can also be elicited by cursor movement
errors in a continuous BCI cursor control task. This work represents a first step toward detecting ErrPs during the daily
home use of a communications BCI. |
| 关键词: Brain computer interface · Error-related potentials · Motor cortex · Dorsolateral pre-frontal conrtex · Locked-in syndrome · Utrecht neural prosthesis |
| DOI：https://doi.org/10.1007/s11768-021-00062-y |
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| 基金项目: |
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| The dorsolateral pre‑frontal cortex bi‑polar error‑related potential in a locked‑in patient implanted with a daily use brain–computer interface |
| Zachary Freudenburg,Khaterah Kohneshin,Erik Aarnoutse,Mariska Vansteensel,Mariana Branco,Sacha Leinders,Max van den Boom,Elmar G. M. Pels,Nick Ramsey |
| (Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands) |
| Abstract: |
| While brain computer interfaces (BCIs) offer the potential of allowing those suffering from loss of muscle control to once
again fully engage with their environment by bypassing the affected motor system and decoding user intentions directly from
brain activity, they are prone to errors. One possible avenue for BCI performance improvement is to detect when the BCI user
perceives the BCI to have made an unintended action and thus take corrective actions. Error-related potentials (ErrPs) are
neural correlates of error awareness and as such can provide an indication of when a BCI system is not performing according
to the user’s intentions. Here, we investigate the brain signals of an implanted BCI user suffering from locked-in syndrome
(LIS) due to late-stage ALS that prevents her from being able to speak or move but not from using her BCI at home on a
daily basis to communicate, for the presence of error-related signals. We first establish the presence of an ErrP originating
from the dorsolateral pre-frontal cortex (dLPFC) in response to errors made during a discrete feedback task that mimics the
click-based spelling software she uses to communicate. Then, we show that this ErrP can also be elicited by cursor movement
errors in a continuous BCI cursor control task. This work represents a first step toward detecting ErrPs during the daily
home use of a communications BCI. |
| Key words: Brain computer interface · Error-related potentials · Motor cortex · Dorsolateral pre-frontal conrtex · Locked-in syndrome · Utrecht neural prosthesis |
