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| DOI：10.10.1007/s11768-010-0030-y |
| Received:January 28, 2010Revised:January 28, 2010 |
| 基金项目:The work was supported by NUS Academic Research Fund (R-263-000-483-112) |
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| Dynamic modelling and control of extracellular ATP concentration on vascular endothelial cells via shear stress modulation |
| Cheng XIANG,Lingling CAO,Kairong QIN,Tong Heng LEE |
| (National University of Singapore (NUS)) |
| Abstract: |
| A new dynamic model for cell-deformation-induced adenosine triphosphate (ATP) release from vascular
endothelial cells (VECs) is proposed in this paper to quantify the relationship between the ATP concentration at the surface
of VECs and blood flow-induced shear stress. The simulation results demonstrate that ATP concentration at the surface
of VECs predicted by the proposed new dynamic model is more consistent with the experimental observations than those
by the existing static and dynamic models. Furthermore, it is the first time that a proportional-integral-derivative (PID)
feedback controller is applied to modulate extracellular ATP concentration. Three types of desired ATP concentration
profiles including constant, square wave and sinusoid are obtained by regulating the wall shear stress under this PID
control. The systematic methodology utilized in this paper to model and control ATP release from VECs via adjusting
external stimulus opens up a new scenario where quantitative investigations into the underlying mechanisms for many
biochemical phenomena can be carried out for the sake of controlling specific cellular events. |
| Key words: Dynamic modeling Control ATP Shear stress Vascular endothelial cells |
